Publications
Our research publications spanning genetics, genomics, and psychiatric disorders.
2025
Genome-wide association studies of lifetime and frequency of cannabis use in 131,895 individuals
Thorpe HHA, Fontanillas P, Meredith JJ, Jennings MV, Cupertino RB, Pakala S, 23andMe Research Team, Elson SL, Khokhar JY, Davis LK, Johnson EC, Palmer AA, Sanchez-Roige S
Molecular Psychiatry
Delay discounting violations vary by adolescent sociodemographics: Excluding nonsystematic data may bias conclusions
Gelino BW, Felton JW, Hung I, Strickland JC, Kahn GD, Thomas NS, Gowin JL, Sloan ME, Palmer AA, Sanchez-Roige S, Sanches MR, Yip SW, Maher BS & Rabinowitz JA
Experimental and Clinical Psychopharmacology
Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits
Johnson EC, Lai D, Miller AP, Hatoum AS, Deak JD, Balbona JV, Baranger DAA, Galimberti M, Sanichwankul K, Thorgeirsson T, Colbert SMC, Sanchez-Roige S […] Edenberg HJ, Gelernter J, Agrawal A
Psychological Medicine
Genomic structural equation study reveals links between anorexia nervosa and delay discounting and perseverance but not other facets of impulsivity
Bianchi SB, Vilar-Ribo L, Palmer AA, Gustavson D, Sanchez-Roige S
Frontiers in Psychiatry
Genome-wide association study of delay discounting in 134,935 23andMe participants
Thorpe HHA, Fontanillas P, Meredith JJ, Jennings MV, Cupertino RB, Pakala S, 23andMe Research Team, Elson SL, Khokhar JY, Davis LK, Johnson EC, Palmer AA, Sanchez-Roige S
Molecular Psychiatry
Genome-wide association study of borderline personality disorder identifies 11 loci and highlights shared risk with mental and somatic disorders
Streit F, Sanchez-Roige S et al.
Nature Genetics
The pleiotropic architecture of human impulsivity across biological scales
Mallard TT, Tubbs J, Jennings M, Zhang Y, Gustavson DE, Grotzinger AD, Westwater ML, Williams CM, Fortgang RG, 23andMe Research Team, Elson SL, Fontanillas P, Raznahan A, Tucker-Drob E, Choi KW, Ge T, Smoller JW, Palmer AA, Sanchez-Roige S
American Journal of Psychiatry
Transdiagnostic and Disorder-Level GWAS Enhance Precision of Substance Use and Psychiatric Genetic Risk Profiles in African and European Ancestries
Khan Y, Davis CN, Jinwala Z, Feuer KL, Toikumo S, Hartwell EE, Sanchez-Roige S, Peterson RE, Hatoum AS, Kranzler HR, Kember RL
Biological Psychiatry
Prescription Opioid Medication Survey: A tool to collect deep phenotypic data on the multifactorial pathways to opioid use disorder in clinical and population-based cohorts
Courchesne-Krak NS, Chandrasekaran AR, Gonzalez J, Bianchi SB, Tran V, Johnson EO, Troiani V, Hettema J, Stein MB, Coon H, Docherty AR, Berrettini W, MacKillop J, de Wit H, Marienfeld C, Palmer AA, Sanchez-Roige S
Complex Psychiatry
Psychiatric Genetics in the Diverse Landscape of Latin American Populations
Bruxel EM, […] Sanchez-Roige S, Santamaría-García H, Shansis FM, Sharp RR, Storch EA, Tavares MEA, Tietz GE, Torres-Hernández BA, Tovo-Rodrigues L, Trelles P, Trujillo-ChiVacuan EM, Velásquez MM, Vera-Urbina F, Voloudakis G, Wegman-Ostrosky T, Zhen-Duan J, Zhou H, Santoro ML, Nicolini H, Atkinson EG, Giusti-Rodríguez P, Montalvo-Ortiz JL
Nature Genetics
RatXcan: A framework for cross-species integration of genome-wide association and gene expression data
Santhanam N*, Sanchez-Roige S*, Liang Y, Chitre AS, Munro D, Chen D, Cheng R, Gao J, George AM, Gileta A, Holl K, Hughson A, King CP, Lamparelli AC, Martin CD, Martinez AG, Mi S, St. Pierre CL, Tripi J, Wang T, Chen H, Flagel S, Ishiwari K, Meyer P, Saba L, Solberg Woods LC, Polesskaya O, Palmer AA, Im HK
PLoS Genetics
Automating the Addiction Behaviors Checklist for Problematic Opioid Use Identification
Chatham AH, Bradley E, Parker C, Beiler D, Troiani V, Schirle L, Sanchez-Roige S, Samuels DC, Jeffery AD
JAMA Psychiatry
Genetic Propensity for Delay Discounting and Educational Attainment in Adults are Associated with Delay Discounting in Preadolescents: Findings from the Adolescent Brain Cognitive Development Study
Rabinowitz JA, Thomas N, Strickland J, Meredith JJ, Hung I-T, Cupertino R, Felton JW, Gelino B, Stone B, Maher B, Dick D, Yi R, Flores-Ocampo V, García-Marín LM, Renteria M, Palmer A, Sanchez-Roige S
Genes, Brain and Behavior
Impulsivity Facets and Substance Use Involvement: Insights From Genomic Structural Equation Modeling
Vilar-Ribo L, Hatoum AS, Grotzinger AG, Mallard TT, 23andMe Research Team, Elson S, Fontanillas P, Palmer AA, Gustavson DE, Sanchez-Roige S
Psychological Medicine
2024
Delay discounting data in the Adolescent Brain Cognitive Development (ABCD) study: Modeling and analysis considerations
Gelino BW, Rabinowitz JA, Maher BS, Felton JW, Yi R, Novak MD, Sanchez-Roige S, Palmer AA, Strickland JC
Experimental and Clinical Psychopharmacology
An emerging multi-omic understanding of the genetics of opioid addiction
Johnson EO, Fisher HS, Sullivan KA, Corradin O, Sanchez-Roige S, Gaddis NC, Sami YN, Townsend A, Teixeira Prates E, Pavicic M, Kruse P, Chesler EJ, Palmer AA, Troiani V, Bubier JA, Jacobson DA, Maher BS
Journal of Clinical Investigation
Identification of transdiagnostic childhood externalizing pathology within an electronic medical records database and application to the analysis of rare copy number variation
Reddy IA, Han L, Sanchez-Roige S, Ruderfer DM, and Davis LK
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Genetic Heterogeneity Across Dimensions of Alcohol Use Behaviors
Savage JE, Barr PB, Phung T, Lee YH, Zhang Y, McCutcheon VV, COGA Investigators, Ge T, Smoller JW, Davis LK, Meyers J, Porjesz B, Posthuma D, Mallard TT, Sanchez-Roige S
American Journal of Psychiatry
A single-nucleus transcriptomic atlas of medium spiny neurons in the rat nucleus accumbens
Crist R, Reiner B, Chehimi S, Merkel R, Toikumo S, Berrettini WH, Kranzler H, Sanchez-Roige S, Kember R, Schmidt H
Scientific Reports
Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking
Johnson EC, Austin-Zimmerman I, Thorpe HHA, Levey DF, Baranger DAA, Colbert SMC, Demontis D, Khokhar JY, Davis LK, Edenberg HJ, Di Forti M, Sanchez-Roige S, Gelernter J, Agrawal A
Neuropsychopharmacology
Rare and common variants associated with alcohol consumption identify a conserved molecular network
Leger BS, Meredith JJ, Ideker T, Sanchez-Roige S*, Palmer AA*
Alcoholism: Clinical and Experimental Research
Genome-wide association study of coffee consumption in 503,675 UK Biobank and 23andMe participants
Thorpe HA, Pham B, Courchesne-Krak N, Bianchi SB, Jennings MV, Elson SL, the 23andMe Research Team, Fontanillas P, Palmer AA, Sanchez-Roige S
Neuropsychopharmacology
Do polygenic indices capture "direct" effects on child externalizing behavior? Within-family analyses in two longitudinal birth cohorts
Tanksley PT, Brislin SJ, Wertz J, de Vlaming R, Courchesne-Krak NS, Mallard TT, Raffington LL, Linnér RK, Koellinger P, Palmer A, Sanchez-Roige S, Waldman I, Dick D, Moffitt TE, Caspi A, Harden KP
Clinical Psychological Science
A phenome-wide association and mendelian randomization study of alcohol variants in a multi-ancestral cohort from 23andMe comprising up to 3 million individuals
Jennings MV*, Martínez-Magaña JJ*, Courchesne-Krak NS*, Cupertino RC*, Bianchi SB, Vilar-Ribó L, Hatoum AS, 23andMe, Inc. Research Team, Elson SL, Edenber HJ, Fontanillas P, Palmer AA & Sanchez-Roige S
Lancet eBiomedicine
Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes
Toikumo S*, Jennings MV*, Lee H, Pham B, Mallard TT, Bianchi SB, Ye GY, Niarchou M, Million Veteran Program, Psychemerge SUD, Hancock D, Xu K, Smoller JW, Davis LK, Justice AC, Kranzler HR, Kember RL, Sanchez-Roige S
Nature Human Behaviour
Medical and genetic correlates of long-term buprenorphine treatment in the electronic health records
Niarchou M, Sanchez-Roige S, Reddy I, Marcovitz D, Davis LK
Translational Psychiatry
2023
Executive function and impulsivity predict distinct genetic variance in internalizing problems, externalizing problems, thought disorders, and compulsive disorders: A genomic structural equation modeling study
Gustavson DE, Morrison CL, Mallard TT, Jennings MV, Fontanillas P, Elson SL, Palmer AA, Friedman NP, Sanchez-Roige S
Clinical Psychological Science
Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program Cohort
Barr PB, Bigdeli TB, Meyers JL, Peterson RE, Sanchez-Roige S, Mallard TT, Dick DM, Harden KP, Wilkinson A, Graham DP, Nielsen DA, Swann A, Lipsky RK, Kosten T, Aslan M; Cooperative Studies Program (CSP) #572; Million Veteran Program, Harvey PD, Kimbrel NA, Beckham JC
JAMA Psychiatry
CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice
Sanchez-Roige S, Jennings MV, Thorpe HHA, Mallari JE, van der Werf LC, Bianchi SB, Huang Y, Lee C, Mallard TT, Barnes SA, Wu JY, Barkley-Levenson AM, Boussaty EC, Snethlage CE, Schafer D, Babic Z, Winters BD, Watters KE, Biederer T, 23andMe Research Team, Mackillop J, Stephens DN, Elson SL, Fontanillas P, Khokhar JY, Young JW & Palmer AA
Translational Psychiatry
Guidelines for Evaluating the Comparability of Down-Sampled GWAS Summary Statistics
Williams CM, Poore H, Tanksley PT, Kweon H, Courchesne-Krak NS, Londono-Correa D, Mallard TT, Barr P, Koellinger PD, Waldman ID, Sanchez-Roige S, Harden KP, Palmer AA, Dick DM, Linnér RK
Behavior Genetics
Shared genetic architecture between attention-deficit/hyperactivity disorder and lifespan
Vilar-Ribó L, Cabana-Domínguez J, Martorell L, Ramos-Quiroga JA, Sanchez-Roige S, Palmer AA, Vilella E, Ribasés M, Muntané G, Artigas MS
Neuropsychopharmacology
Multi-ancestry study of the genetics of problematic alcohol use in >1 million individuals
Zhou H, Kember RL, Deak JD, Xu H, Toikumo S, Yuan K, Lind PA, Farajzadeh L, Wang L, Hatoum AS, Johnson J, Lee H, Mallard TT, Xu J, Johnston KJA, Johnson EC, Galimberti M, Dao C, Levey DF, Overstreet C, Byrne EM, Gillespie NA, Gordon S, Hickie IB, Whitfield JB, Xu K, Zhao H, Huckins LM, Davis LK, Sanchez-Roige S, Madden PAF, Heath AC, Medland SE, Martin NG, Ge T, Smoller JW, Hougaard DM, Børglum AD, Demontis D, Krystal JH, Gaziano JM, Edenberg HJ, Agrawal A, Million Veteran Program, Justice AC, Stein MB, Kranzler HR, Gelernter J
Nature Medicine
Identifying problematic opioid use in electronic health record data: Are we looking in the right place?
Schirle L, Kwun S, Suh A, Sanchez-Roige S, Jeffery AD, Samuels DC
Journal of Opioid Management
Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders
Hatoum AS, Colbert SMC, Johnson EC, Huggett SB, Deak JD, Pathak G, Jennings MV, Paul SE, Karcher NR, Hansen I, Baranger DAA, Edwards A, Grotzinger A, Substance Use Disorder Working Group of the Psychiatric Genomics Consortium, Tucker-Drob EM, Kranzler HR, Davis LK, Sanchez-Roige S, Polimanti R, Gelernter J, Edenberg HJ, Bogdan R, Agrawal A
Nature Mental Health
2022
Genetic investigation of the contribution of body composition to anorexia nervosa in an electronic health record setting
Mack T, Sanchez-Roige S, & Davis LK
Translational Psychiatry
Parsing Genetically Influenced Risk Pathways: Genetic Loci Impact Problematic Alcohol Use Via Externalizing and Specific Risk
Barr PB, Mallard TT, Sanchez-Roige S, Poore HE, Linner RK, COGA Collaborators, Waldman ID, Palmer AA, Harden KP, Dick DM
Translational Psychiatry
Substance use and common contributors to morbidity: a genetics perspective
Sanchez-Roige S, Kember RL & Agrawal A
eBioMedicine
Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects on brain
Kember RL, Vickers-Smith R, Xu H, Toikumo S, Niarchou M, Zhou H, Hartwell E, Crist RC, Rentsch CT, Million Veterans Program, Davis LK, Justice AC, Sanchez Roige S, Kampman KM, Gelernter J, Kranzler HR
Nature Neuroscience
Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci
Deak JD, Zhou H, Galimberti M, Levey DF, Wendt FR, Sanchez-Roige S, Hatoum AS, Johnson EC, Nunez YZ, Demontis D, Børglum AD, Rajagopal VM, Jennings MV, Kember RL, Justice AC, Edenberg HJ, Agrawal A, Polimanti R, Kranzler HR, Gelernter J
Molecular Psychiatry
Cross-ancestry genomic research: time to close the gap
Atkinson EG, Bianchi SB, Ye GY, Martínez-Magaña JJ, Tietz GE, Montalvo-Ortiz JL, Giusti-Rodriguez P, Palmer AA, Sanchez-Roige S
Neuropsychopharmacology
A phenome-wide association study of polygenic scores for attention deficit hyperactivity disorder across two genetic ancestries in electronic health record data
Niarchou M, Sealock JM, Straub P, Sanchez-Roige S, Sutcliffe JS, Davis LK
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Polygenic Transcriptome Risk Scores Can Translate Genetic Results Between Species
Santhanam N*, Sanchez-Roige S*, Liang Y, Chitre AS, Munro D, Chen D, Cheng R, Gao J, George AM, Gileta A, Holl K, Hughson A, King CP, Lamparelli AC, Martin CD, Martinez AG, Mi S, St. Pierre CL, Tripi J, Wang T, Chen H, Flagel S, Ishiwari K, Meyer P, Saba L, Solberg Woods LC, Polesskaya O, Palmer AA, Im HK
Genome Biology
Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities
Mallard TT, Linner RK, Grotzinger AD, Sanchez-Roige S, Seidlitz J, Okay A, de Vlaming R, Meddens SFW, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Palmer AA, Davis LK, Tucker-Drob EM, Kendler KS, Keller MC, Koellinger PD, Harden KP
Cell Genomics
Accelerating opioid use disorders research by integrating multiple data modalities
Bianchi SB, Jeffery AD, Samuels DC, Schirle L, Palmer AA, Sanchez-Roige S
Complex Psychiatry
Identifying high-risk comorbidities associated with opioid use patterns using electronic health record prescription data
Jennings MV, Lee H, Rocha DB, Bianchi SB, Coombes BJ, Crist RC, Faucon A, Hu Y, Kember RL, Mallard TT, Niarchou M, Poulsen MN, Straub P, Urman RD, Walsh CG, PsycheMERGE Substance Use Disorder Workgroup, Davis LK, Smoller JW, Troiani V, Sanchez-Roige S
Complex Psychiatry
Evaluation of delay discounting as a transdiagnostic research domain criteria indicator in 1388 general community adults
Levitt EE, Oshri A, Amlung M, Ray LA, Sanchez-Roige S, Palmer AA, MacKillop J
Psychological Medicine
A mutant allele of Neuronal Membrane Glycoprotein M6-B (Gpm6b) facilitates behavioral flexibility but increases delay discounting
Sanchez-Roige S, Barnes S, Mallari J, Wood R, Polesskaya O, Palmer AA
Genes, Brain and Behavior
Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts
Mallard TT, Savage JE, Johnson EC, Huang Y, Edwards AC, Hottenga JJ, Grotzinger AD, Gustavson DE, Jennings MV, Anokhin A, Dick DM, Edenberg HJ, Kramer JR, Lai D, Meyers JL, Pandey AK, Harden KP, Nivard MG, de Geus EJC, Boomsma DI, Agrawal A, Davis LK, Clarke T, Palmer AA & Sanchez-Roige S
American Journal of Psychiatry
2021
Two Data-Driven Approaches to Identifying the Spectrum of Problematic Opioid Use: A Pilot Study within a Chronic Pain Cohort
Schirle L, Jeffery A, Yaqoob A, Sanchez-Roige S, Samuels DC
International Journal of Medical Informatics
Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry
Sanchez-Roige S, Fontanillas P, Jennings MV, Bianchi SB, Huang Y, Hatoum A, Sealock J, Davis LK, Elson SL, 23andMe Research Team & Palmer AA
Molecular Psychiatry
Dimensional phenotypes in psychiatric genetics: lessons from genome-wide association studies of alcohol use disorders
Mallard TT & Sanchez-Roige S
Complex Psychiatry
Mapping Pathways by which Genetic Risk Influences Adolescent Externalizing Behavior: The Interplay between Externalizing Polygenic Risk Scores, Parental Knowledge, and Peer Substance Use
Kuo SI, Salvatore JE, Barr PB, Aliev F, Anokhin A, Bucholz KK, Chan G, Edenberg HJ, Hesselbrock V, Kamarajan C, Kramer JK, Lai D, Mallard TT, Nurnberger JI, Pandey G, Plawecki MH, Sanchez-Roige S, Waldman I, Palmer AA & Dick DM
Behavior Genetics
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction
Karlsson Linnér R, Mallard TT, Barr PB, Sanchez-Roige S, Madole JW, Driver MN, Poore HE, de Vlaming R, Grotzinger AD, Tielbeek JJ, Johnson EC, Liu M, Rosenthal SB, Ideker T, Zhou H, Kember RL, Pasman JA, Verweij KJH, Liu DJ, Vrieze S, COGA Collaborators, Kranzler HR, Gelernter J, Harris KM, Tucker-Drob EM, Waldman ID, Palmer AA, Harden KP, Koellinger PD & Dick DM
Nature Neuroscience
Alcohol and cigarette smoking consumption as genetic proxies for alcohol misuse and nicotine dependence
Sanchez-Roige S, Cox NJ, Johnson EO, Hancock DB & Davis LK
Drug and Alcohol Dependence
Integration of Evidence across Human and Model Organism Studies: A Meeting Report
Rohan P, Johnson E, Won H, Polimanti R, Kapoor M, Chitre A, Bogue M, Benca-Bachman C, Parker C, Ursu O, Verma A, Reynolds T, Ernst J, Bray M, Kwon SB, Lai D, Quach B, Gaddis N, Saba L, Chen H, Hawrylycz M, Zhang S, Zhou Y, Mahaffey S, Fischer C, Sanchez-Roige S, Bandrowski A, Qing L, Shen L, Phillip V, Gelernter J, Bierut L, Hancock D, Edenberg H, Johnson EN, Barr P, Prins P, Smith D, Akbarian S, Thorgeirsson T, Walton D, Baker E, Jacobsen D, Palmer AA, Miles M, Chesler E, Emerson J, Agrawal A, Martone M, Williams R
Genes, Brain and Behavior
Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies
Munn-Chernoff MA et al.
Addiction Biology
Polygenic contributions to alcohol use and alcohol use disorders across population-based and clinically ascertained samples
Johnson EC*, Sanchez-Roige S*, Acion L, Adams MJ, Bucholz KK, Chan G, Chao MJ, Chorlian DB, Dick DM, Edenberg HJ, Foroud T, Hayward C, Heron J, Hesselbrock V, Hickman M, Kendler KS, Kinreich S, Kramer J, Kuo SI, Kuperman S, Lai D, McIntosh AM, Meyers JL, Plawecki MH, Porjesz B, Porteous D, Schuckit MA, Su J, Zang Y, Palmer AA, Agrawal A, Clarke TK, Edwards A
Psychological Medicine
2020
A large-scale genome-wide association study meta-analysis of cannabis use disorder
Johnson EC, Demontis D, Thorgeirsson TE, Walters RK, Polimanti R, Hatoum AS, Sanchez-Roige S, Paul SE, Wendt FR, Clarke TK, Lai D, et al.
Lancet Psychiatry
Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits
Zhou H, Sealock JM, Sanchez-Roige S, Clarke TK, Levey DF, Cheng Z, Li B, Polimanti R, Kember RL, Smith RV, Thygesen JH, Morgan MY, Atkinson SR, Thursz MR, Nyegaard M, Mattheisen M, Børglum AD, Johnson EC, Justice AC, Palmer AA, McQuillin A, Davis LK, Edenberg HJ, Agrawal A, Kranzler HR, Gelernter J
Nature Neuroscience
Steep Discounting of Future Rewards as an Impulsivity Phenotype: A Concise Review
Levitt E, Sanchez-Roige S, Palmer AA, MacKillop J
Current Topics in Behavioral Neurosciences
Emerging phenotyping strategies to advance our understanding of psychiatric genetics
Sanchez-Roige S & Palmer AA
Nature Neuroscience
The Latent Genetic Structure of Impulsivity and its Relation to Internalizing Psychopathology
Gustavson D, Friedman N, Fontanillas F, Elson SL, 23andMe Research Team, Palmer AA, Sanchez-Roige S
Psychological Science
Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium
Polimanti R, Walters RK, Johnson EC, McClintick JN, Adkins AE, Adkins DE, Bacanu SA, Bierut LJ, Bigdeli TB, Brown S, Bucholz KK, Copeland WE, Costello EJ, Degenhardt L, Farrer LA, Foroud TM, Fox L, Goate AM, Grucza R, Hack LM, Hancock DB, Hartz SM, Heath AC, Hewitt JK, Hopfer CJ, Johnson EO, Kendler KS, Kranzler HR, Krauter K, Lai D, Madden PAF, Martin NG, Maes HH, Nelson EC, Peterson RE, Porjesz B, Riley BP, Saccone N, Stallings M, Wall TL, Webb BT, Wetherill L, Psychiatric Genomics Consortium Substance Use Disorders Workgroup, Edenberg HJ, Agrawal A, Gelernter J
Molecular Psychiatry
2019
Recent efforts to dissect the genetic basis of alcohol use and abuse
Sanchez-Roige S*, Palmer AA, Clarke TK
Biological Psychiatry
Phenome-wide investigation of health outcomes associated with genetic predisposition to loneliness
Abdellaoui A, Sanchez-Roige S, Sealock J, Treur JL, Dennis J, Fontanillas P, Elson S, 23andme Research Team, Nivard MG, Ip HF, van der Zee M, Baselmans BML, Hottenga JJ, Willemsen G, Mosing M, Lu Y, Pedersen NL, Denys D, Amin N, van Duijn CM, Szlagyi I, Tiemeier H, Neumann A, Verweij KJH, Cacioppo S, Cacioppo JT, Davis LK, Palmer AA, Boomsma DI
Human Molecular Genetics
Genetic risk for major depressive disorder and loneliness in sex-specific associations with coronary artery disease
Dennis L, Sealock J, Levinson R, Farber-Eger E, Franco J, Fong S, Straub P, Hucks D, Song WL, Linton M, Fontanillas P, Elson S, Ruderfer D, Abdellaoui A, Sanchez-Roige S, Palmer AA, Boomsma D, Cox N, Chen G, Mosley J, Wells Q and Davis LK
Molecular Psychiatry
Electronic health records are the next frontier for the genetics of substance use disorders
Sanchez-Roige S* and Palmer AA
Trends in Genetics
Genome-Wide Association Studies of Impulsive Personality Traits (BIS-11 and UPPS-P) and Drug Experimentation in up to 22,861 adult research participants
Sanchez-Roige S, Fontanillas P, Elson SL, 23andMe Research Team, Gray GC, de Wit H, MacKillop J, Palmer AA
Journal of Neuroscience
Genomic Basis of Delayed Reward Discounting
Gray JC, Sanchez-Roige S, de Wit H, MacKillop J, Weafer J & Palmer AA
Behavioural Processes
Genetic Influences on Delayed Reward Discounting: A Genome-wide Prioritized Subset Approach
MacKillop J, Gray JC, Weafer J, Sanchez-Roige S, Palmer AA & de Wit H
Experimental and Clinical Psychopharmacology
Genome-wide study identifies 611 loci associated with risk tolerance and risky behaviours
Linner RK et al.
Nature Genetics
2018
Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts
Sanchez-Roige S, Palmer AA, Fontanillas P, Elson SL, 23andMe Research Team, Substance Use Disorder Working Group of the Psychiatric Genomics Consortium, Adams MJ, Howard DM, Edenberg HJ, Davies G, Crist RC, Deary I, McIntosh AM, Clarke TK
American Journal of Psychiatry
Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Walters RK et al.
Nature Neuroscience
Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use
Pasman JA et al.
Nature Neuroscience
Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry
Sanchez-Roige S, Fontanillas P, Elson SL, 23andMe Research Team, Pandit A, Foerster JR, Abecasis GR, Gray GC, de Wit H, Davis L, MacKillop J, Palmer AA
Nature Neuroscience
2017
The genetics of human personality
Sanchez-Roige S, Gray GC, MacKillop J, Chi-Hua C, Palmer AA
Genes, Brain and Behavior
Genome-wide association study of Alcohol Use Disorder Identification Test (AUDIT) scores in 20,328 research participants of European ancestry
Sanchez-Roige S, Fontanillas P, Elson SL, 23andMe Research Team, Gray GC, de Wit H, Davis L, MacKillop J, Palmer AA
Addiction Biology
2016
Genome-Wide Association Study of Loneliness Demonstrates a Role for Common Variation
Gao J, Davis LK, Hart AB, Sanchez-Roige S, Han L, Cacioppo J, Palmer AA
Neuropsychopharmacology
Heightened impulsivity: associated with family history of alcoholism, and a consequence of alcohol intake
Sanchez-Roige S, Stephens DN, Duka T
Alcoholism: Clinical and Experimental Research
Mouse and human genetic analyses associate kalirin with ventral striatal activation during impulsivity and with alcohol misuse
Pena-Oliver Y, Carvalho FM, Sanchez-Roige S, … Schumann G, Stephens DN
Frontiers in Genetics
2015
The novel mu-opioid antagonist, GSK1521498, reduces ethanol consumption in C57BL/6J mice
Ripley TL, Sanchez-Roige S, Bullmore ET, Mugnaini M, Maltby K, Miller SR, Wille DR, Nathan P, Stephens DN
Psychopharmacology
Voluntary Exercise Promotes Beneficial Anti-aging Mechanisms in SAMP8 Female Brain
Bayod S, Guzmán-Brambila C, Sanchez-Roige S, Lalanza JF, Kaliman P, Ortuño-Sahagun D, Escorihuela RM, Pallas M
Journal of Molecular Neuroscience
Alleviating waiting impulsivity and perseverative responding by µ-opioid receptor antagonism in two inbred mouse strains
Sanchez-Roige S, Ripley TL, Stephens DN
Psychopharmacology
2014
Repeated ethanol exposure during early and late adolescence: double dissociation of effects on motor and choice impulsivity
Sanchez-Roige S, Peña-Oliver Y, Ripley T, Stephens DN
Alcoholism: Clinical and Experimental Research
Long-term wheel running changes on sensorimotor activity and skeletal muscle in male and female mice of accelerated senescence
Sanchez-Roige S, Lalanza JF, Alvarez-Lopez MJ, Cosin-Tomas M, Griñan-Ferré C, Pallas M, Kaliman P, Escorihuela RM
AGE
Exaggerated waiting impulsivity associated with human binge drinking, and high alcohol consumption in mice
Sanchez-Roige S, Baro V, Trick L, Peña-Oliver Y, Stephens DN, Duka T
Neuropsychopharmacology
Alpha-synuclein deletion decreases motor impulsivity but does not affect risky decision making in a mouse Gambling Task
Pena-Oliver Y, Sanchez-Roige S, Stephens DN, Ripley TL
Psychopharmacology
Macroautophagic process was differentially modulated by long-term moderate exercise in rat brain and peripheral tissues
Bayod S, Del Valle J, Pelegri C, Vilaplana J, Canudas AM, Camins A, Jimenez A, Sanchez-Roige S, Lalanza JF, Escorihuela RM, Pallas M
Journal of Physiology and Pharmacology
Epigenetic alterations in hippocampus of SAMP8 senescent mice and modulation by voluntary physical exercise
Cosin-Tomas M, Alvarez-Lopez MJ, Sanchez-Roige S, Lalanza JF, Bayod S, Pallas M, Escorihuela RM, Kaliman P
Frontiers in Aging Neuroscience
Wnt pathway regulation by long-term moderate exercise in rat hippocampus
Bayod S, Menella I, Sanchez-Roige S, Lalanza JF, Escorihuela RM, Camins A, Pallas M, Canudas AM
Brain Research
2013
Long-term exercise modulates hippocampal gene expression in senescent female mice
Alvarez-Lopez MJ, Castro-Freire M, Cosin-Tomas M, Sanchez-Roige S, Lalanza JF, Del Valle J, Parrizas M, Camins A, Pallas M, Escorihuela RM, Kaliman P
Journal of Alzheimer's Disease
2012
Measuring impulsivity in mice: the five-choice serial reaction time task
Sanchez-Roige S, Pena-Oliver Y, Stephens DN
Psychopharmacology
Physiological and behavioural consequences of long-term moderate treadmill exercise
Lalanza JF, Sanchez-Roige S, Gagliano H, Fuentes S, Bayod S, Camins A, Pallas M, Armario A, Escorihuela RM
Psychoneuroendocrinology
Long-term physical exercise induces changes in sirtuin 1 pathway and oxidative parameters in adult rat tissues
Bayod S, Del Valle J, Lalanza JF, Sanchez-Roige S, de Luxan-Delgado B, Coto-Montes A, Canudas AM, Camins A, Escorihuela RM, Pallas M
Experimental Gerontology
2011
Long-term treadmill exercise induces neuroprotective molecular changes in rat brain
Bayod S, Del Valle J, Canudas AM, Lalanza JF, Sanchez-Roige S, Camins A, Escorihuela RM, Pallas M
Journal of Applied Physiology